Folate Status Linked to Cancer Cell ProliferationRemember, correlation is not causation.
While folate is essential for one-carbon metabolism and biological methylation reactions, some evidence suggests that folic acid supplementation may increase cancer risk. In a cross-sectional analysis, Tomaszewski and colleagues investigated serum and tissue folate in prostate cancer patients and cancer-free controls. Interestingly, serum and tissue folate levels were higher in men with prostate cancer versus levels of cancer-free controls. Unlike the controls, the cancer patients’ serum folate positively correlated with prostate tissue folate content. In patients with Gleason 7 disease, those with the highest serum folate also had the highest level of proliferation markers in cancer tissue. These findings suggest a positive relationship between folate status and the proliferation of prostate tumors, although it is unclear how dietary and supplemental folic acid and folate metabolism are involved.
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