Here are three of his most recent posts on this topic (I guess more will follow over time):
- Here about his mB12 protocol
- Here a bit more on the the mB12-protocol
- And here video from Dr. Rich van Konynenburg
Well, the last time I followed a protocol (cpnhelp's Vitamin D and N-Acetylcysteine NAC) I got worse – so I am a bit hesitant to try any "protocol" at the moment.
And firstly, I need to understand WHAT and how much I should take under this protocol. There are so many B-vitamins (and related compounds) that it is a bit difficult to keep an overview on what exactly to take. There seems to be a lot of fine tuning involved and considering that I feel sometimes better and sometimes worse it is easy to fool oneself. And there seem to be different "schools of thought", which worries me a bit, that there a people "fine tuning" a protocol that does little or no good.
The second thing is I want to understand WHY. I want to know the rationale behind it all, I want to understand the mechanisms, I want to understand the metabolism pathways, I want to see (at least) partial evidence, objective measurable values. As far as I know, the mechanisms behind the "methylation block" are purely speculative – the protocol may (or may not) help, for a few or some (or even most) of the ME/CFS patients, but I call quack BS on the putative mechanisms. Without a proper test that can distinguish ME/CFS patients without methylation blockage from ME/CFS patients with methylation blockage – and subsequential test whether the methylation protocol helps this subgroup! – I am a bit worried about this "one size fits all" approach.
PS: He made a new version of his collection of ME/CFS resources, were he tries to exclude pseudo-science (like XMRV), for which I applaud him. Personally, as I consider all currently proposed disease mechanisms for ME/CFS to be – regardless who proposed them – as either