Thursday, May 24, 2012

ME/CFS is a Women's Disease

Some people (mainly male doctors?) have the misogynistic perception that because ME/CFS affects more women than men, it must therefore be some form of female hysteria ("It's the vapors."). Well, I say bullshit to that. There are several autoimmune diseases that affect more women than men – a slight hint (not more, I'm afraid) that ME/CFS might share some disease mechanisms with autoimmune diseases:
Ratio of female/male incidence of autoimmune diseases:
Hashimoto's thyroiditis 10/1
Systemic lupus erythematosus (SLE) 9/1
Graves' disease 7/1
Rheumatoid arthritis 5/2
Multiple sclerosis (MS) 2/1
Myasthenia gravis 2/1
The 23andme blog this topic:
Why women are disproportionately affected by autoimmune disease is not fully known or understood, although the hypotheses are numerous. Some research suggests that estrogen may help antibody production and immune system response, but can also lead to an overly active immune system. Other research indicates that genes on the X chromosomes may play a role in these immune system mutinies, and women — who have two X chromosomes — may thus be at an increased risk over men who have only one X chromosome.

Still other research suggests that “fetal-maternal microchimerism” may be the root cause. In this strange-sounding phenomenon, a small number of the baby’s cells pass through the placenta into the mother and continue to live within the mother. The presence of these foreign fetal cells within the mother may result in an incorrect immune system response and autoimmune disease. More research, however, is needed to establish which of these hypotheses (if any) are correct.

Autoimmune diseases are serious medical concerns for women; indeed, when taken together, autoimmune diseases constitute one of the top ten causes of death among young and middle-aged women. The irony of these conditions is that the immune system, which should be a woman’s greatest ally in fighting disease, becomes her worst enemy. Why and how a body’s betrayal occurs needs to be better understood through further research.

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