Dear Jo Nijs,I really had to watch my language with such fine research from such fine researchers.
I have a question regarding one of your results.
You state that:
"From the available literature, it is concluded that musculoskeletal factors are unlikely to account for pain from CFS."
My question originates from the 2009 study "Light AR, White AT, Hughen RW, Light KC. Moderate exercise increases expression for sensory, adrenergic, and immune genes in chronic fatigue syndrome patients but not in normal subjects." that you cite in your paper.
I was under the impression that the data by the author Alan Light actually suggest that it are the sensory nerve endings on the muscles that sense increased fatigue (and in extension pain) in CFS (and Fibromyalgia).
E.g. as Alan Light says here in a lecture (at minute 4:11):
I would like to ask what suggest that the increased expression of sensory genes in peripheral blood cells is a phenomenon occurring centrally, and what makes you think that changes in peripheral blood are a central phenomenon and therefore "unlikely" to originate from musculoskeletal factors.
Saturday, September 22, 2012
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