Look AHEAD trial stopped
Eat less, move more, have your heart attack on time!
With apologies for lack of any attention to the blog recently (which may be set to continue for some time) but this snippet just had to get passed on. This link from Karl:
http://www.theheart.org/article/1458351.do
More info here
http://www.nih.gov/news/health/oct2012/niddk-19.htm
And the glowing anticipation of success here from the planning stage:
https://www.lookaheadtrial.org/public/home.cfm
Pubmed gives a series of genuine success stories from the early days on all sorts of parameters. But the cardiovascular end points show how utterly useless these interventions are long term.
However the massive omission, from the quick look I've managed, is of any intention to report the all cause mortality. It seems very likely to me that more people died in the intervention group than in the usual care group, but p was > 0.05.
Call me a cynic, but I think they stopped the trial because they could see where that p number was heading. Has anyone seen a body count from anywhere in the trial?
Also, what might the outcome have been if the intervention group had been repeatedly bullied, harassed and indoctrinated to maintain a normoglycaemic, low grade ketogenic diet for 13.5 years? Say to an HbA1c of around 5%?
Ha ha ha bloody ha.
Peter
[Update]: And Seth Roberts on the topic.
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