Migraine Joke

How many people do you need to investigate migraine?

Genome-wide meta-analysis identifies new susceptibility loci for migraine
Verneri Anttila
Bendik S Winsvold
Padhraig Gormley
Tobias Kurth
Francesco Bettella
George McMahon
Mikko Kallela
Rainer Malik
Boukje de Vries
Gisela Terwindt
Sarah E Medland
Unda Todt
Wendy L McArdle
Lydia Quaye
Markku Koiranen
M Arfan Ikram
Terho Lehtimäki
Anine H Stam
Lannie Ligthart
Juho Wedenoja
Ian Dunham
Benjamin M Neale
Priit Palta
Eija Hamalainen
Markus Schürks
Lynda M Rose
Julie E Buring
Paul M Ridker
Stacy Steinberg
Hreinn Stefansson
Finnbogi Jakobsson
Debbie A Lawlor
David M Evans
Susan M Ring
Markus Färkkilä
Ville Artto
Mari A Kaunisto
Tobias Freilinger
Jean Schoenen
Rune R Frants
Nadine Pelzer
Claudia M Weller
Ronald Zielman
Andrew C Heath
Pamela A F Madden
Grant W Montgomery
Nicholas G Martin
Guntram Borck
Hartmut Göbel
Axel Heinze
Katja Heinze-Kuhn
Frances M K Williams
Anna-Liisa Hartikainen
Anneli Pouta
Joyce van den Ende
Andre G Uitterlinden
Albert Hofman
Najaf Amin
Jouke-Jan Hottenga
Jacqueline M Vink
Kauko Heikkilä
Michael Alexander
Bertram Muller-Myhsok
Stefan Schreiber
Thomas Meitinger
Heinz Erich Wichmann
Arpo Aromaa
Johan G Eriksson
Bryan J Traynor
Daniah Trabzuni
North American Brain Expression Consortium UK Brain Expression Consortium Elizabeth Rossin
Kasper Lage
Suzanne B R Jacobs
J Raphael Gibbs
Ewan Birney
Jaakko Kaprio
Brenda W Penninx
Dorret I Boomsma
Cornelia van Duijn
Olli Raitakari
Marjo-Riitta Jarvelin
John-Anker Zwart
Lynn Cherkas
David P Strachan
Christian Kubisch
Michel D Ferrari
Arn M J M van den Maagdenberg
Martin Dichgans
Maija Wessman
George Davey Smith
Kari Stefansson
Mark J Daly
Dale R Nyholt
Daniel I Chasman
Aarno Palotie
for the International Headache Genetics Consortium

I am now migraine free, after having figured out my nutrition. I was able to stop using Ibuprofen – something that was before unthinkable for me.

Will they ever find out? They did "brain tissue expression quantitative trait locus analysis" after all. Should count for something, shouldn't it?

Idiots.

And Nature, that bloody tabloid.

Are Migraines Caused By The Liver?

I just had an epiphany:
What if the headache from an migraine is the same thing as the headache from an post-alocohol hangover? What if actually it is a problem in the liver that is causing headaches in both cases?

ipRGCs

…
Studies on migraine headaches, which are often exacerbated by bright lights, are revealing another role of ipRGCs in the human brain. Harvard headache researcher Rodrigo Noseda had observed that light could trigger migraines even in blind people; he therefore theorized that the headaches might be triggered by ipRGCs. To explore the idea, he dissected the brains of rats, staining both ipRGCs and pain-signaling neurons to trace their paths.The ipRGCs connect to pain neurons in the thalamus, he found, suggesting that exposure to light could disturb pain-signaling neurons as well. Light sensitivity can be devastating for some migraine sufferers. They can’t drive, write, or even read. Once researchers understand the pathway well enough to manipulate it pharmacologically, such patients might find relief.

Unfortunately, switching off the ipRGCs entirely is not a viable option. These neurons are now known to extend into the thalamus, a region of the brain known for promoting awareness. Presumably they deliver some kind of essential information there. When neuroscientists find out what kind of message it is, they will make real progress—perhaps toward fighting pain, and definitely toward getting a better look at our secret selves.