In a reminder of how much a once-heralded area of lung cancer research has crumbled, a former Duke oncologist and his colleagues issued their eighth study retraction late last week.
On Friday, Dr. Anil Potti and his co-authors formally withdrew a 2008 study in the Journal of the American Medical Association (JAMA) that purported to offer a "genetic signature" that would show which patients with breast cancer would respond to a particular treatment.
The authors write in a statement on the JAMA website -- available at bit.ly/AeIufY -- that they are retracting the paper because it was based on a method they now believe is unreliable. That approach -- which no one has been able to reproduce -- was described in a now-withdrawn paper in the journal Nature Medicine in 2006.
The case is yet another example of researchers -- some of whom had financial interests in the method -- being overly enthusiastic about findings that held great promise for very sick patients, but that did not hold up to scrutiny.
Sunday, January 15, 2012
Retractions, retractions, retractions
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