Monday, January 23, 2012

What research has the WPI done since October 2009?

The only thing that comes to my mind is the 2011 Vincent Lombardi cytokine study.

The cancer study thing didn't seem to have gone anywhere.

The 33 PCR negative patients from the Science paper? Done by 10/2009.

The claim to have found XMRV in autism (6/15)? Done by 10/2009.

The claim to have found XMRV in atypical MS (3/3)? Done by 10/2009.

The claim to have found XMRV in fibromyalgia (12/20)? Done by 10/2009.

Usage of qRT-PCR in the context of treatment? Done by 10/2009.

All presented by Daniel Peterson on the CFSAC October 2009 meeting.

The Blood Working Group (BWG)? Done at VIPDx.

Any other research regarding "XMRV" at the WPI? Anything? Am I missing anything?

There is one list of studies that seems to have gone nowhere:
Current Research Program (June 2010)

Role of Chronic Inflammatory and Immune Stimulation by Active Herpesvirus Infection in the Development of Immune Dysfunction in CFS
Studies of immune abnormalities in this CFS cohort will involve phenotypic analysis of NK, DC, and T cell populations. States of activation and differentiation will be studied to determine whether the cells are immune activators or suppressors due to response to infection. The goal is to understand the imbalance in the immune system that leads to unregulated virus expression.
Collaborators: Francis Ruscetti, PhD, NIC, Dennis Taub PhD, NIA (INIP Research Award)

Novel Viruses/Co-infections in Subgroups of CFS
A Virus DNA Microarray (Virochip) was used to screen a cohort of CFS with Immunological defects and increased incidence of Mantle cell lymphoma (MCL).
Collaborators: Francis Ruscetti, PhD, Cancer Inflammation Program, NCI

Role of the Interferon/RNaseL Antiviral Pathway in CFS
The goal of this study is to characterize defects in the Interferon/RNaseL antiviral pathway which result in viral persistence.
Collaborators: Robert Silverman, PhD, Cleveland Clinic

Role of Inflammatory Cytokines and Chemokines in CFS
The purpose of this study is to identify and develop the serum biomarker patterns of cytokine and chemokines, which correlate with clinical disease and can be used to monitor intervention.
Collaborators: Dennis D. Taub, PhD, NIA

Host Susceptibility in CFS
The goal of this study is to elucidate genetic factors of susceptibility and the dysregulation of the host defense system in order to develop biomarkers for diagnostic development and thus predict response to immune modulating therapy and vaccines.
Collaborators: Jonathan R. Kerr, MD, PhD, St. Georges University, London UK,
Mary Carrington, PhD, NCI, Mike Dean, PhD, NCI

Enumeration and Function of Natural Killer (NK) Cells in CFS
The purpose of this project is to develop improved NK diagnostic tests for both the number and function of NK cells.
Collaborators Doug Redelman, PhD, UNR, Dept. of Microbiology & Immunology

Epidemiologic Evaluation of Lymphoma and Cancer Incidence in Nevada CFS Cohort
The goal of this study is to determine if a possible cancer cluster exists in the cohort of Nevada CFS patients.
Collaborators: Paul Levine, MD, George Washington University

Study of Clonal T Cell Receptor-gamma Rearrangements in Nevada CFS Cohort
The purpose of this study is to determine the significance of clonal T cell receptor-gamma rearrangements in the pathogenesis of CFS.
Collaborators: Dorothy Hudig, PhD, UNR, Dept. of Microbiology & Immunology

Development of a Whole Genome Transcriptome Assay for HHV6
The goal is to develop a whole genome transcriptome assay for HHV6 and a sub array for HHV6A specific detection to be used as a diagnostic tool or research tool to understand the viral life cycle in disease.
Collaborators: Rachel Bagni, PhD, Applied Technology Program, NCI

HHV6 Latency in CFS
The goal of this study is to understand the role of HHV6A latency in bone marrow hematopoietic stem cells in the pathogenesis of CFS.
Collaborators: Stephen St. Joer, PhD
Marianna Bego, PhD, UNR, Dept. of Microbiology & Immunology

And there is this (from 2009?):
Clinical/Translational Research Program

Study Title and DescriptionCollaborators
Development of Clinical Application for Cytokine Profiling of ME/CFS Patients
Patients with particular cytokine and chemokine profiles will be evaluated to identify specific clinical traits of characteristics with the goal to correlate these traits with specific environmental or infectious triggers.

Investigation of Active Human Cytomegalovirus (HCMV) Infections in ME/CFS Patients
The goal of these studies is to determine whether active HCMV infections can be detected in the blood of ME/CFS patients, and if so, to determine its prevalence and clinical manifestations.

Konnie Knox, PhD
Don Carrigan, PhD, Wisconsin Viral Research Group
Confirm and Extend Observations of Persistent Enterovirus Infection in Subpopulation of ME/CFS Patients
The goal of this study is to correlate EV positivity with clinical phenotype, cytokine profile, "leaky gut," co-infections.

Konnie Knox, PhD
Don Carrigan, PhD, Wisconsin Viral Group
Define Predictors of Positive Clinical Response to Treatment of ME/CFS Patients with Antivirals, e.g., Valcyte and Visitide
The goal of this study is to determine the differences in clinical phenotype between antiviral Responders and Non Responders. Compare R and NR Cytokines, viral infections, RNaseL activity, blood counts, NK cell activity, etc.
Konnie Knox, PhD
Don Carrigan, PhD, Wisconsin Viral Research Group
I guess throwing people under the bus is more important than science.

I found Dr. Mikovits stash of unpublished studies!

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