Friday, February 17, 2012

"Folate Status Linked to [Prostate] Cancer Cell Proliferation"

Folate Status Linked to Cancer Cell Proliferation

While folate is essential for one-carbon metabolism and biological methylation reactions, some evidence suggests that folic acid supplementation may increase cancer risk. In a cross-sectional analysis, Tomaszewski and colleagues investigated serum and tissue folate in prostate cancer patients and cancer-free controls. Interestingly, serum and tissue folate levels were higher in men with prostate cancer versus levels of cancer-free controls. Unlike the controls, the cancer patients’ serum folate positively correlated with prostate tissue folate content. In patients with Gleason 7 disease, those with the highest serum folate also had the highest level of proliferation markers in cancer tissue. These findings suggest a positive relationship between folate status and the proliferation of prostate tumors, although it is unclear how dietary and supplemental folic acid and folate metabolism are involved.
Remember, correlation is not causation.

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