Wednesday, February 29, 2012

Revisiting oldies but goodies - Another one

Revisiting oldies but goodies.
http://news.sciencemag.org/scienceinsider/2011/10/xmrv-researcher-fired.html


Mikovits's collaborator, Francis Ruscetti of the National Cancer Institute (NCI) in Frederick, Maryland, who ran all of the Western blots, confirms that the Ottawa slide uses the same image that appears in Lombardi et al.
So wait, did I get his right, Ruscetti ran all of the Western Blots in Lombardi et al. 2009?

So what did the WPI do, except write one sentence about the 68 PCR positive patient samples?
Ruscetti and Mikovits, in a joint e-mail to Science for this article, said many patients and their doctor, Daniel Peterson (who since has had a falling out with WPI), knew the original coded numbers, so the researchers changed them for the Science publication to "protect the patient privacy." Ruscetti says it was a mistake for Mikovits to have used the original patient codes in Ottawa. "We were under so much pressure, we missed it," says Ruscetti.
Yeah, but at least one of the so called "original coded numbers", the number 1282 that appear on the Mikovits' Slide of Shame (which I shall rename Ruscetti/Mikovits Slide of Shame) appeared as well in the study itself – in the Addendum! Either Ruscetti/Mikovits don't recall what they did – or the words "bear false witness" come to my mind.

(And please note how someone is trying to throw Daniel Peterson under the bus.)
As far as the use of 5-azacytidine, Ruscetti and Mikovits stressed in their e-mail that "there was no attempt in the original paper to hide anything." They say for the purposes of Lombardi et al., the use of 5-azacytidine was not germane: They were simply trying to demonstrate that CFS patients had viral proteins not seen in controls. By the time of the Ottawa meeting, they say they realized that this experiment did not in fact show XMRV but proteins from a broader family of gammaretroviruses.
In fact they had to realize that they forgot to run a control for the usage of 5-AZA! Oh, the rush of writing something for Science!

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