1. "At the July workshop, Dr. Mikovits also presented preliminary data showing that 20 patients of the 101 in the study have lymphoma, a rare form of cancer. The link between XMRV and lymphoma is still being investigated, but it raised the possibility that XMRV may be associated with other cancers in addition to prostate cancer. NCI's Dr. Le Grice said studies will be launched to determine whether XMRV is associated with other diseases. At the Whittemore Peterson Institute, Dr. Mikovits said they also found XMRV in people with autism, atypical multiple sclerosis and fibromyalgia."
Cancer-Causing Virus Linked to Chronic Fatigue
BY AMY DOCKSER MARCUS
OCTOBER 12, 2009.
2. "Since reliable, consistent information about the Science cohort has not been forthcoming, I have carefully analyzed data provided in the Science paper, its supplement and public presentations by two of the authors. The WPI investigators conducted a number of assays to detect XMRV DNA, protein, infectious virus and antibodies against XMRV. I used the patient ID numbers provided in the paper's figures to track results. Of the 101 CFS subjects reported in the paper, results for the various assays are shown for only 32 CFS subjects. Of the 32 CFS subjects whose results for any of the tests are displayed, 12 CFS subjects were positive for XMRV on more than one assay. The other 20 CFS subjects were documented as positive by just one testing method. Using information from a public presentation at the federal CFS Advisory Committee, four of the 12 CFS subjects (WPI 1118, 1150, 1199 and 1125) included in the Science paper were also reported to have cancer – either lymphoma, mantle cell lymphoma or myelodysplasia. The presentation reported that 17 WPI repository CFS subjects with cancer had tested positive for XMRV. This once again raises questions about the lack of detailed clinical characteristics of the CFS subjects included in the Science paper, and the differing public reports about where the samples originated."
Playing A Weak Hand Well
Suzanne D. Vernon, PhD
The CFIDS Association of America
3. Q: Were any patients with lymphoma mentioned in the XMRV study?
A: Blood samples from the WPI repository were chosen at random and there were no patients chosen with lymphoma or mention of lymphoma in this study. Another preliminary study was done at a later date that had nothing to do with the XMRV Science publication.
4. Q: Did any of the samples used in the original study come from patients who ultimately developed cancer?
A: Yes, one.
5. From the NCI's Center for Cancer Research 2009 CCR Scientific Advances-
Detection of a retrovirus, XMRV, in blood products of patients with neurological diseases and cancer – submission by Francis Ruscetti, PhD
Reference(s): Science. 2009 Oct 23; 326(5952): 585-9
source- (webpage no longer online, a saved copy does exist)
(Note- Not sure what the exact import of the title is, since although the reference given is the WPI's XMRV/Science paper, Science was contacted and asked if the WPI/XMRV paper had ever had this or any other title than the one it was published with, which Science said it had no record of this. Given the above inconsistancies though, it kind of raises some questions)
6. By comparing information in the 'XMRV Association with CFS' presentation given to the CFSAC on October 29-30, 2009, with Table 4- 'XMRV detection results of 101 patients' in 'Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome' in the Journal Virulence, at least 12 patients from the original XMRV/Science study had cancer, although its impossible to tell exactly due to only 93 patient numbers being listed in the table and not the full 101 stated. One more patient number which was listed as previously having had cancer in the CFSAC presentation, 1199, is included in Tables 1 and 2 but not Table 4. The cancer status of one of these patients, 1125, was known as far back as the year 2000.
6a. WPI patients w/ cancer, taken from pt. 5 of 'XMRV Association with CFS' presentation given on October 29-30, 2009-
6b. 'XMRV Association with CFS' - Part 5- presentation given to the CFSAC on October 29-30, 2009- (see Slide 1)
6c. 'Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome' Virulence 1:5, 386-390; September/October 2010- (see Table 4)
6d. WPI 1125- http://i55.tinypic.com/2a8f495.jpg
Sunday, February 26, 2012
Patients with Cancer in Lombardi 2009?
A comment on ERVs blog:
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